Furosemide is a drug and representatives of the so-called loop diuretics that inhibit a transport protein (the sodium potassium chloride Cotransporter) in the ascending part of the loop of Henle in the kidney and lead to the Elimination of large quantities of lymph. Venous dose of the drug, precipitation amounts of up to 50 liters per day are possible. Furosemide was patented in 1962 by Hoechst.
At oral, furosemide is divided into the Biopharmaceutics classification system due to its poor solubility and poor permeability in the class IV. The low solubility is based above all on the acidity structure, which involves a very low solubility at low pH values. Furosemide is reasonably soluble at neutral pH. The bad permeability is due to some affinity to an intestinal efflux, but so far not yet properly described.
Indications officially approved in accordance with manufacturer's specifications are hypertension, ascites and oedema (including brain oedema) about due to heart failure or as a result of liver, kidney disease or burns, under certain circumstances also drohendes renal failure. In addition, furosemide is used when hyperkalemia, to flush excess potassium.

In sport, it is used as acrylic, since it helps any traces of collected drugs from the body to flush, which is why it is to find on the doping list.

Furosemide promotes the water excretion through the kidneys.

Every minute, more than a liter of blood flows through the fine filter of the kidney bodies - where a large proportion of the fluid filter. Complex regulatory and exchange mechanisms ensure then that unnecessary substances be singled out. Important blood components and minerals, however, return back into the bloodstream. Only waste salts, toxic degradation products of metabolism and the excess water is collected in the bladder and excreted.
Furosemide is a Entwässerungsmittel (diuretic). It inhibits transport mechanisms of kidney, carrying the minerals back into the blood. In this way, it promotes the excretion of sodium, potassium, chloride, magnesium and calcium. Each of these substances binds liquid itself, so that more water is excreted - increases the amount of urine.

Decrease of water content in the blood reduces the amount of blood that is pumped from the heart throughout the body. This relieves the heart and blood pressure lowered. Water that is converted from the blood vessels in the tissue is pulled back again into the bloodstream. Thus, water retention can be washed in the tissue (edema). Highly effective diuretics such as furosemide, inhibit the Mineralstofftransport exactly where, the management system of the kidney's body to a loop is bent at the - they are referred to as a loop diuretic.

In the weakness of the kidney function furosemide increases the performance of the kidney and the amount of urine. You will have to travel at the beginning of the therapy the toilet a probably more often. To be able to sleep at night without interruption, it is advisable to take the medication in the morning.
Side effects

The most important, well-known side effects are listed. They can occur, not but have to, because everyone responds differently to medicines.

Sometimes, people react allergic to drugs. Should you have the signs of an allergic reaction, tell your doctor or pharmacist immediately.
Metabolic disorders, e.g. change of blood glucose, blood lipid levels
Dehydration causes dry mouth, fatigue and headaches. Strong liquid deficiency possible confusion and hypotension with tendency to collapse.
Decrease in potassium levels in the blood (hypokalemia) with symptoms such as dizziness, weakness, stomach problems, constipation, arrhythmia
Increased uric acid levels
Leg cramps
Loss of minerals (sodium, potassium, magnesium, calcium)
Blockage of veins by a blood clot (thrombosis) (rare)

LASIX 40 for Chron. Glomerulonephritis, nephrot. Syndrome with gout, muscle spasms

The compatibility is basically good, but I have 2 very unpleasant NW of LASIX. One is a (sometimes) b.1, recurrent gout at the big toe. The other concerns very unpleasant seizures, especially in lower and upper thighs, but also in the arms and fingers. The cramps are sometimes so severe that it drives the tears in the eyes.

for abdominal ascites, pleural effusion with muscle spasms

Very strong water tablets, which have only a duration of a few hours, that is you, one must take after about 5 hours again, so that there is an increased Hanrauscheidung. LASIX is under the water tablets. Confuses the complete electrolyte budget. I had such strong cramps in various places, that I had to bring the doctor even once. I would recommend as alternative FuroCT or Spyrobeta.

Furosemide has in addition some further applications:
When a pulmonary edema, furosemide reached a
rapid and intensive fluid leakage during.
Like other loop diuretics, furosemide is used the
Prevention of acute renal failure and treatment of renal functional weakness.
Furosemide is used for the treatment of high blood pressure or a
High blood pressure crisis in the framework of the heart and circulatory complaints.
With furosemide in the form of tablets not sufficient urinary excretion occurs, the active ingredient as injection can be administered.

Is this substance for what purposes?
Increase excretion of sodium, potassium, calcium and magnesium
Increase renal blood flow
Promote water precipitations
Relieve heart
Lower blood pressure.